Heart Rate Reduction by Ivabradine: Slowly but Surely?
نویسندگان
چکیده
منابع مشابه
Together, Slowly but Surely
That objective reference is necessary for formation of reliable beliefs about the external world is almost axiomatic. However, Condorcet (1785) suggested that purely subjective information--if shared and combined via social interaction--is enough for accurate understanding of the external world. We asked if social interaction and objective reference contribute differently to the formation and b...
متن کاملHeart-rate reduction by If-channel inhibition with ivabradine restores collateral artery growth in hypercholesterolemic atherosclerosis.
AIMS Collateral arteries protect tissue from ischaemia. Heart rate correlates with vascular events in patients with arterial obstructive disease. Here, we tested the effect of heart-rate reduction (HRR) on collateral artery growth. METHODS AND RESULTS The I(f)-channel inhibitor ivabradine reduced heart rate by 11% in wild-type and 15% in apolipoprotein E (ApoE)(-/-) mice and restored endothel...
متن کاملHeart rate reduction by ivabradine improves aortic compliance in apolipoprotein E-deficient mice.
BACKGROUND Impaired vascular compliance is associated with cardiovascular mortality. The effects of heart rate on vascular compliance are unclear. Therefore, we characterized effects of heart rate reduction (HRR) by I(f) current inhibition on aortic compliance and underlying molecular mechanisms in apolipoprotein E-deficient (ApoE(-)/(-)) mice. METHODS ApoE(-)/(-) mice fed a high-cholesterol ...
متن کاملIvabradine: heart rate and left ventricular function.
intravenous administration of ivabradine caused no serious adverse events, with only four mild adverse events possibly related to ivabradine, all of which resolved spontaneously on the same day. Thus, Manz et al. [1] demonstrated that ivabradine is not just another reducer of heart rate. It is the only compound that can reduce heart rate without affecting any other hemodynamic parameter and wit...
متن کاملHeart rate reduction with ivabradine improves energy metabolism and mechanical function of isolated ischaemic rabbit heart.
AIMS The anti-anginal agent ivabradine slows heart rate (HR) by selectively inhibiting the I(f) current in the sinus node. We report an ex vivo study to evaluate the anti-ischaemic effect of ivabradine in terms of modulation of cardiac energy metabolism. METHODS AND RESULTS A Langendorff-perfused rabbit heart model was subjected to low-flow ischaemia and reperfusion. Cardiac metabolism was st...
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ژورنال
عنوان ژورنال: American Journal of Respiratory Cell and Molecular Biology
سال: 2020
ISSN: 1044-1549,1535-4989
DOI: 10.1165/rcmb.2020-0364ed